Enantioselective C-H arylation strategy for functionalized dibenzazepinones with quaternary stereocenters.
نویسندگان
چکیده
Tada! Highly functionalized chiral dibenzazepinones are obtained by a mild palladium(0)-catalyzed enantioselective C-H arylation with excellent selectivities by using simple taddol phosphoramidite ligands. The amide tether allows exclusive regioselectivity through a rare eight-membered palladacycle intermediate.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 30 شماره
صفحات -
تاریخ انتشار 2013